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Pethe says that the candidate drug will move on to phase I clinical trial.
The molecule belongs to a new class of synthetic chemicals with no similarities to existing drugs. This factor could make it tougher for the bacteria to develop resistance to it. Valerie Mizrahi, a TB biologist at the University of Cape Town in South Africa, says the study "affirms the notion that there are new TB drug targets out there waiting to be discovered by screening diverse compound libraries. This is good news for the field and it must be celebrated". Next stepsSuccess at this stage does not guarantee that the compound will lead to an effective treatment in humans.
TB in mice.
ill pass tests due to the chemicals going undetected in their system. Det Insp Colfs said it was for that reason that synthetics were also becoming increasingly popular with criminals subject to bail conditions which prohibit drug and alcohol use. Synthetic cannabis is commonly sold as a herbal Saucony Shadow 5000 Red
remedy, but Det Insp Colfs said the chemicals used could kill and urged anyone with information about local distribution to contact police. A new drug candidate has shown promising signs in treating tuberculosis. The synthetic molecule Saucony Outlet New York is effective in mice and bears no similarity to existing TB drugs, many of which have become inadequate as drug resistant bacterial strains have developed. If it is shown to be safe and effective in humans, it could help to combat a disease that killed 1.
4 million people in 2011. A team led by Kevin Pethe, a microbiologist at the Pasteur Institute Korea near Seoul, investigated more than 120,000 compounds over 5 years, infecting mouse immune cells called macrophages with Mycobacterium tuberculosis the bacterium that causes TB and observing whether candidate compounds inhibited bacterial growth. "We are able to look at infection directly inside macrophage cells, allowing us to screen a large number of chemical libraries more quickly," says Pethe. Saucony Shadow 5000
tuberculosis growth. Subsequent tests showed the compound to be successful at treating Saucony New York Manhattan
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