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, 60 d post inoculation. We measured titers of intrapulmonary RSV, lung interferon Saucony Grid 8000 Shrimp
These findings in Saucony Ignition 5 guinea pigs suggest a possible Saucony Peregrine
We have developed a guinea pig model of experimental RSV infection in which lung function and airway inflammation have been studied in association with RSV persistence (8,14). In this model, intranasal RSV inoculation of juvenile CH results in a productive lung infection that is associated with nonspecific AHR and airway inflammation by lymphocytes and granulocytes, including T cells and eosinophils (8,15,16). After resolution of the acute infection, CH develop a persistent lung infection characterized by ongoing, low level RSV replication, AHR, and airway eosinophilia (8,14,15).
role for RSV p.
(IFN) and interleukin (IL) 5 mRNA expression, AHR and airway T cells and eosinophils. All virus inoculated groups of animals showed evidence of persistent RSV lung infection; however, Th2 skewed guinea pigs had virus associated AHR and significantly greater levels of airway T cells and eosinophils. In conclusion, RSV can establish persistent infection of the guinea pig lung regardless of host Th1/Th2 background; however; a host Th1 background limits the extent of virus associated AHR and airway inflammation.
ODN, cytosine phosphate guanine oligodeoxynucleotides; OA, ovalbumin; PC2, provocative concentration of ACh associated with a doubling of baseline; pfu, plaque forming units; RL, lung resistance; RSV, respiratory syncytial virus; STR2, strain 2 guinea pigs; Th1 (2), T helper 1 (2)RSV is the most common cause of acute bronchiolitis, the leading cause of infant hospitalization in the developed world (1). However, the consequences of chronic intrapulmonary RSV persistence are unclear (13).
Heterogeneity in virus host interactions may be relevant to understanding why some children hospitalized for RSV bronchiolitis go on to develop recurrent wheezing/asthma symptoms. Abbreviations: ACh, acetylcholine; AHR, airway hyperresponsiveness; AOI, area of interest; CH, Cam Hartley guinea pigs; CpG Saucony Boston Marathon Shoes
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