donderdag, 31 mei 2012

Saucony Black Shadow

Saucony Black Shadow

Saucony Black Shadow

immunoprophylaxis of CH) on the development of RSV persistence and virus associated AHR and Saucony Black And Gold

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´╗┐ersistence in the pathogenesis of AHR and airway inflammation that have features similar to asthma (17). Importantly, CH are a genetically outbred strain that is highly susceptible to allergic sensitization relative to inbred STR2 or STR13 (18). STR2 are comparatively allergy resistant, as Saucony Excursion

We have recently shown that CpG ODN immunoprophylaxis of CH inhibits the viral component of RSV enhanced allergic sensitization to aerosolized OA (21), suggesting that CpG ODN could potentially be useful for limiting the extent of RSV infection in these animals. In the current study, we examined the role of host Th1 background, either genetic (STR2) or induced (CpG ODN Saucony Kineta Relay Review

these animals do not readily sensitize to foreign antigens (19) and release less histamine in response to ovalbumin (OA) challenge when passively sensitized with anti OA IgG antibody (20). We have previously reported that RSV inoculated STR2 develop an acute lung infection characterized by AHR, airway inflammation by T cells and eosinophils, and a Th2 shift in the lung gene expression ratios of IFN (Th1 cytokine) to IL 5 (Th2 cytokine), but with lower titers Saucony Black Shadow of intrapulmonary replicating virus than observed in more allergy susceptible animals (16,21).

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airway inflammation 60 d post inoculation (7). CH were used as the reference allergy susceptible stra.

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Long term outcomes of RSV infection regarding the possibility of viral persistence, AHR, and airway inflammation in STR2 have not yet been reported. Because host Th1 responses are considered important for effective antiviral immunity and viral clearance (22,23), we were interested in determining whether STR2 can eradicate RSV from the lungs or whether they develop a persistent infection (and the virus associated AHR and airway inflammation) that has been described in allergy susceptible CH. In na CH, intranasal administration of CpG ODN is well tolerated and produces a Th1 shift in the lung IFN gene expression ratio (21).

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